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New Formulation & Vehicle Evaluation
New Formulation & Vehicle Evaluation


New Formulation & Vehicle Evaluation

In the context of new formulation evaluation projects assigned by sponsors, our work involves the Method development and validation for the analysis of biomolecules (such as peptides and small molecule drugs), using advanced analytical instrumentation, such as HPLC-MS/MS. We use our methods to perform release assay studies of drugs from novel particles (such as liposomes, PLGA particles, etc.) either in in-vitro appropriate medium simulating in vivo settings (e.g. different pH conditions, lysosomes, etc.) or in in-vivo suitable matrices (e.g. plasma or serum).

IWe then design Pharmacokinetic studies in appropriate animal models (e.g, mouse or rat) depending on the question that needs to be addressed.  The process includes the identification of: i) the optimal route of administration (e.g., IP, IV or PO), ii) the proper protocol for sample collection (time points).Finally, upon execution of experiment and analysis we perform quantitative and statistical data analysis and generate reports for the new formulation.


Partner Institute

Biomedical Research Foundation of the Academy of Athens

Biomedical Research Foundation of the Academy of Athens

Constantin Tamvakopoulos – Investigator A’, Professor Level
Center of Clinical, Experimental Surgery & Translational Research
Director of Research, Pharmacology Lab,
Biomedical Research Foundation, Academy of Athens (BRFAA),
Soranou Ephessiou 4
Athens, 11527
Tel: +30 210 6597 475
+30 210 6597 484