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Mission of HTRI/EATRIS-GR in the Research Infrastructure Landscape

HTRI/EATRIS-GR provides services focusing specifically on preclinical and early-phase-clinical development of drugs, therapeutics and biomedical devices. The specific services provided are outlined in the figure bellow which illustrates the preclinical and early-phase-clinical services that are available to academic and/or industrial users, the existing relevant facilities and the partner institutions providing the relevant facilities. The multidisciplinary nature of translational research is illustrated by indicating the overlapping infrastructures required for supporting a Phase-I Clinical Trial (red arrows) and a Preclinical in vivo evaluation of a drug/therapeutic (blue arrows). The strong complementarity of EATRIS-GR with other Research Infrastructures and the potential for strong synergies (such as the expansion of activities into the Phase IIa Clinical Trial area in cooperation with PMed-GR) is illustrated at the top section of the figure. EATRIS-GR complements and synergizes with other RIs such as INSPIRED (involving Instruct-EL), BIOIMAGING, Infrafrontiers, ELIXIR-GR and BBMRI-GR that are not shown in the scheme since they support the entire development pipeline. *PK Data Analysis refers to “Determination of pharmacokinetic parameters/clinical end points and statistical evaluation of data obtained from Preclinical and Early-Clinical Trials. 

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